The Maremma region of Tuscany is a little more remote, but combines the hills and the coast. It is well connected to the rest of Italy - so how you get there depends on where you're coming from and how much mobility you want when you're there.
Rome (FCO) - many direct flights from the US and UK, about 2h drive.
Florence (FLR) - connecting from the US, direct from the UK, also about 2h drive.
Milan (MXP or LIN) - for those who love a road-trip, about 4h 30min drive.
Leave the airport and take A-12 / E-80 Northbound (direction Civitavecchia). Eventually just north of Civitavecchia, the toll highway/motorway runs out and becomes the SS-1. It reverts to freeway just south of Grosseto. In total it’s 113 miles heading north; then take the exit for Braccagni onto SP-152 south, then a left to SP-157 east. La Pescaia is about 3 miles on the right.
Leave the airport and head over to A-1 / E-35 South (direction Roma) and in about 5 miles take SS-223 South (direction Siena). Stay on SS-223 after Siena (direction Grosseto). About 65 miles on SS-223 in total. Take the exit to Roccastrada. After Roccastrada, (about 6 miles) turn left onto the SP-157 and La Pescaia is 6 miles on the left.
For those of you on a grand European driving vacation, you'll likely be coming in via Genoa and Pisa. You'll stay on the A-12 South (direction Roma) before taking the exit to SP-152 South (direction Braccagni). Turn almost immediately left onto the SP-157 and La Pescaia is 3 miles on the right.
About 3 hours - mostly along the coast of the Tyrrhenian Sea.
1. Regional train from FCO to Roma Termini (central Rome); about 0h 30m and €14.
2. Frecciabianca train from Roma Termini to Grosseto (direction Pisa); about 1h 45m
3. Regional train from Grosseto to Sticciano (direction Siena); about 0h 20m
it may be better to take a taxi from Grosetto as there is not much at Sticciano station.